Drug Distribution in the Body

After absorption, drugs enter the bloodstream and are distributed throughout the body, a process known as drug distribution. The distribution of a drug is influenced by various factors, including blood flow to different tissues, the drug's affinity for binding proteins, and the permeability of cellular membranes. Highly perfused tissues such as the liver, heart, and kidneys receive drugs more rapidly than less perfused tissues, affecting the rate and extent of drug distribution. Additionally, dr...